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IP3 kinase B

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Target id: 1448

Nomenclature: IP3 kinase B

Family: Inositol 1,4,5-trisphosphate 3-kinases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 946 1q42.12 ITPKB inositol-trisphosphate 3-kinase B
Mouse - - Itpkb inositol 1,4,5-trisphosphate 3-kinase B
Rat - 934 13q26 Itpkb inositol-trisphosphate 3-kinase B
Previous and Unofficial Names Click here for help
IP3-3KB | IP3KB | inositol 1,4,5-trisphosphate 3-kinase B | insP 3-kinase B | inositol 1
Database Links Click here for help
Alphafold P27987 (Hs), P42335 (Rn)
BRENDA 2.7.1.127
ChEMBL Target CHEMBL5165 (Hs)
Ensembl Gene ENSG00000143772 (Hs), ENSMUSG00000038855 (Mm), ENSRNOG00000002969 (Rn)
Entrez Gene 3707 (Hs), 320404 (Mm), 54260 (Rn)
Human Protein Atlas ENSG00000143772 (Hs)
KEGG Enzyme 2.7.1.127
KEGG Gene hsa:3707 (Hs), mmu:320404 (Mm), rno:54260 (Rn)
OMIM 147522 (Hs)
Pharos P27987 (Hs)
UniProtKB P27987 (Hs), P42335 (Rn)
Wikipedia ITPKB (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.1.127

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GNF362 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.1 pIC50 1
⤷ pIC50 8.1 (IC50 9x10-9 M) [1]
Immunopharmacology Comments
IP3 kinase B (ITPKB) as an essential mediator of T cell activation, whose inhibition is considered a novel approach to treat autoimmune disease [1]. ITPKB inhibition blocks T-cell dependent antibody responses in vivo. GNF362 is a non-selective inhibitor of all three of the IP3 kinases in the family to which ITPKB belongs.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0045059 positive thymic T cell selection IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0002262 myeloid cell homeostasis IEA
GO:0033030 negative regulation of neutrophil apoptotic process IEA
GO:0045638 negative regulation of myeloid cell differentiation IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes, IEA only
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GO:0045059 positive thymic T cell selection IEA
GO:0045638 negative regulation of myeloid cell differentiation IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0045059 positive thymic T cell selection IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA

References

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1. Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA, Parker A, Schmedt C, Stinson M, Avis J et al.. (2015) Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS ONE, 10 (6): e0131071. [PMID:26121493]

How to cite this page

Inositol 1,4,5-trisphosphate 3-kinases: IP3 kinase B. Last modified on 20/04/2017. Accessed on 01/10/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1448.