Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	946	1q42.12	ITPKB	inositol-trisphosphate 3-kinase B
Mouse	-	-		Itpkb	inositol 1,4,5-trisphosphate 3-kinase B
Rat	-	934	13q26	Itpkb	inositol-trisphosphate 3-kinase B

Previous and Unofficial Names

IP3-3KB | IP3KB | inositol 1,4,5-trisphosphate 3-kinase B | insP 3-kinase B | inositol 1

Database Links
Alphafold	P27987 (Hs), P42335 (Rn)
BRENDA	2.7.1.127
ChEMBL Target	CHEMBL5165 (Hs)
Ensembl Gene	ENSG00000143772 (Hs), ENSMUSG00000038855 (Mm), ENSRNOG00000002969 (Rn)
Entrez Gene	3707 (Hs), 320404 (Mm), 54260 (Rn)
Human Protein Atlas	ENSG00000143772 (Hs)
KEGG Enzyme	2.7.1.127
KEGG Gene	hsa:3707 (Hs), mmu:320404 (Mm), rno:54260 (Rn)
OMIM	147522 (Hs)
Pharos	P27987 (Hs)
UniProtKB	P27987 (Hs), P42335 (Rn)
Wikipedia	ITPKB (Hs)

Enzyme Reaction
EC Number: 2.7.1.127

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference GNF362 Hs Inhibition 8.1 pIC50 1 ⤷ pIC50 8.1 (IC50 9x10-9 M) [1]

Immunopharmacology Comments

IP3 kinase B (ITPKB) as an essential mediator of T cell activation, whose inhibition is considered a novel approach to treat autoimmune disease [1]. ITPKB inhibition blocks T-cell dependent antibody responses in vivo. GNF362 is a non-selective inhibitor of all three of the IP3 kinases in the family to which ITPKB belongs.

Immuno Process Associations

Immuno Process:  T cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling