Inositol 1,4,5-trisphosphate 3-kinases | Enzymes | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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Inositol 1,4,5-trisphosphate 3-kinases

Inositol 1,4,5-trisphosphate 3-kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Inositol 1,4,5-trisphosphate 3-kinases (E.C. 2.7.1.127, ENSFM00250000001260) catalyse the generation of inositol 1,3,4,5-tetrakisphosphate (IP₄) from IP₃. IP₃ kinase activity is enhanced in the presence of calcium/calmodulin (CALM2, CALM3, CALM1, P62158) [1].

Enzymes

IP₃ kinase A Show summary »« Hide summary

Target Id

1447

Nomenclature

IP₃ kinase A

Previous and unofficial names

Genes

ITPKA (Hs), Itpka (Mm), Itpka (Rn)

Ensembl ID

ENSG00000137825 (Hs), ENSMUSG00000027296 (Mm), ENSRNOG00000005284 (Rn)

UniProtKB AC

P23677 (Hs), Q8R071 (Mm), P17105 (Rn)

EC number

2.7.1.127

Inhibitors

GNF362 pIC₅₀ 7.7 [2]

IP₃ kinase B Show summary »« Hide summary More detailed page go icon to follow link

IP₃ kinase C Show summary »« Hide summary

References

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How to cite this family page

Database page citation:

Inositol 1,4,5-trisphosphate 3-kinases. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=280.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.