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PLD1

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Target id: 1433

Nomenclature: PLD1

Family: Phosphatidylcholine-specific phospholipase D

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1074 3q26.31 PLD1 phospholipase D1
Mouse - 1074 3 11.15 cM Pld1 phospholipase D1
Rat - 1074 2q24 Pld1 phospholipase D1
Previous and Unofficial Names Click here for help
Choline phosphatase 1 | phosphatidylcholine-hydrolyzing phospholipase D1 | phospholipase D1 | Pld1a | Pld1b | phospholipase D1, phosphatidylcholine-specific
Database Links Click here for help
Alphafold Q13393 (Hs), Q9Z280 (Mm), P70496 (Rn)
BRENDA 3.1.4.4
CATH/Gene3D 3.30.1520.10, 2.30.29.30
ChEMBL Target CHEMBL2536 (Hs), CHEMBL3309054 (Mm), CHEMBL3308939 (Rn)
Ensembl Gene ENSG00000075651 (Hs), ENSMUSG00000027695 (Mm), ENSRNOG00000028156 (Rn)
Entrez Gene 5337 (Hs), 18805 (Mm), 25096 (Rn)
Human Protein Atlas ENSG00000075651 (Hs)
KEGG Enzyme 3.1.4.4
KEGG Gene hsa:5337 (Hs), mmu:18805 (Mm), rno:25096 (Rn)
OMIM 602382 (Hs)
Pharos Q13393 (Hs)
UniProtKB Q13393 (Hs), Q9Z280 (Mm), P70496 (Rn)
Wikipedia PLD1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.4.4
Endogenous activators (Human)
ADP-ribosylation factor 1 (ARF1, P84077), PIP2, RhoA, PKC evoked phosphorylation, RalA  [1-2]
Endogenous inhibitor (Human)
Gβγ  [3]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
FIPI Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.0 pIC50 4
⤷ pIC50 8.0 (IC50 9.5x10-9 M) [4]
compound 69 [PMID: 19136975] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.3 pIC50 4
⤷ pIC50 7.3 (IC50 4.6x10-8 M) [4]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling

References

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1. Hammond SM, Jenco JM, Nakashima S, Cadwallader K, Gu Q, Cook S, Nozawa Y, Prestwich GD, Frohman MA, Morris AJ. (1997) Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem, 272 (6): 3860-8. [PMID:9013646]

2. Luo JQ, Liu X, Hammond SM, Colley WC, Feig LA, Frohman MA, Morris AJ, Foster DA. (1997) RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem Biophys Res Commun, 235 (3): 854-9. [PMID:9207251]

3. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. (2006) Direct modulation of phospholipase D activity by Gbetagamma. Mol Pharmacol, 70 (1): 311-8. [PMID:16638972]

4. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol, 5 (2): 108-17. [PMID:19136975]

How to cite this page

Phosphatidylcholine-specific phospholipase D: PLD1. Last modified on 10/07/2018. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1433.