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Gene and Protein Information ![]() |
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Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 0 | 466 | 18q23 | KCNG2 | potassium voltage-gated channel modifier subfamily G member 2 | 5 |
Mouse | 6 | 0 | 480 | 18 E3 | Kcng2 | potassium voltage-gated channel, subfamily G, member 2 | |
Rat | 6 | 0 | 480 | 18q12.3 | Kcng2 | potassium voltage-gated channel modifier subfamily G member 2 |
Previous and Unofficial Names ![]() |
KCNF2 | KCNG2 | cardiac potassium channel subunit (Kv6.2) | potassium channel, voltage gated modifier subfamily G, member 2 | potassium voltage-gated channel |
Database Links ![]() |
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Alphafold | Q9UJ96 (Hs), Q9QYU3 (Rn) |
Ensembl Gene | ENSG00000178342 (Hs), ENSMUSG00000059852 (Mm), ENSRNOG00000053640 (Rn) |
Entrez Gene | 26251 (Hs), 240444 (Mm), 307234 (Rn) |
Human Protein Atlas | ENSG00000178342 (Hs) |
KEGG Gene | hsa:26251 (Hs), mmu:240444 (Mm), rno:307234 (Rn) |
OMIM | 605696 (Hs) |
Pharos | Q9UJ96 (Hs) |
RefSeq Nucleotide | NM_012283 (Hs), NM_001190373 (Mm), NM_001107372 (Rn) |
RefSeq Protein | NP_036415 (Hs), NP_001177302 (Mm), NP_001100842 (Rn) |
UniProtKB | Q9UJ96 (Hs), Q9QYU3 (Rn) |
Wikipedia | KCNG2 (Hs) |
Associated Proteins ![]() |
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Ion Selectivity and Conductance ![]() |
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Tissue Distribution ![]() |
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Functional Assays ![]() |
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Physiological Functions ![]() |
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Gene Expression and Pathophysiology ![]() |
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Biologically Significant Variants ![]() |
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Biologically Significant Variant Comments | ||||||||||||||
A total of 1190 SNPs have been identified in human KCNG2. For more information please see the entry on GeneCards. |
General Comments |
Kv6.2 has no function on its own, but plays a role in modulation of Kv2 channels. |
1. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 291 (5): L993-1004. [PMID:16815889]
2. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 287 (1): L226-38. [PMID:15047570]
3. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J Physiol (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]
4. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]
5. Zhu XR, Netzer R, Böhlke K, Liu Q, Pongs O. (1999) Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. Recept Channels, 6 (5): 337-50. [PMID:10551266]
Attali B, Chandy KG, Giese MH, Grissmer S, Gutman GA, Jan LY, Lazdunski M, Mckinnon D, Nerbonne J, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Trimmer JS, Wang X. Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F81/2023.1.