Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	339	Xq21.1	P2RY10	P2Y receptor family member 10
Mouse	7	328	X D	P2ry10	purinergic receptor P2Y, G-protein coupled 10
Rat	7	388	Xq31	P2ry10	P2Y receptor family member 10

Previous and Unofficial Names

purinergic receptor P2Y10 | purinergic receptor P2Y, G-protein coupled 10 | purinergic receptor P2Y

Database Links
Specialist databases
GPCRdb	p2y10_human (Hs)
Other databases
Alphafold	O00398 (Hs), Q8BFU7 (Mm)
ChEMBL Target	CHEMBL3562166 (Hs), CHEMBL3562168 (Mm)
Ensembl Gene	ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)
Entrez Gene	27334 (Hs), 78826 (Mm), 317219 (Rn)
Human Protein Atlas	ENSG00000078589 (Hs)
KEGG Gene	hsa:27334 (Hs), mmu:78826 (Mm), rno:317219 (Rn)
OMIM	300529 (Hs)
Pharos	O00398 (Hs)
RefSeq Nucleotide	NM_014499 (Hs), NM_172435 (Mm), NM_001177682 (Rn)
RefSeq Protein	NP_055314 (Hs), NP_766023 (Mm), NP_001171153 (Rn)
UniProtKB	O00398 (Hs), Q8BFU7 (Mm)
Wikipedia	P2RY10 (Hs)

Natural/Endogenous Ligands
LPA
sphingosine 1-phosphate
Comments: Proposed ligands, single publication

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference sphingosine 1-phosphate Hs Agonist 7.3 pEC50 2 ⤷ pEC50 7.3 [2] LPA Hs Agonist 6.9 pEC50 2 ⤷ pEC50 6.9 [2]

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference dioctanoylglycerol pyrophosphate Hs Antagonist - - 2 ⤷ [2] JTE-013 Hs Antagonist - - 2 ⤷ [2]

Tissue Distribution
Platelets Expression level:  High Species:  Human Technique:  qRT-PCR (microarray analysis) and western blotting References:  1
B-cells Expression level:  High Species:  Mouse Technique:  Northern blot, subtractive hybridisation References:  3
Placenta, uterus, prostate, brain, lung, and skeletal muscle Expression level:  High Species:  Mouse Technique:  RT-PCR References:  2

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  N3H Global MAF (%):  19 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 7|24|49|1 Minor allele count:  C=0.187/311 SNP accession:  VAR_033481, rs6618868 Validation:  1000 Genomes, HapMap