Top ▲

Class A Orphans C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide More detailed introduction go icon to follow link

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [26], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [17]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

GPR3GPR4GPR6GPR12GPR15GPR17GPR20
GPR22GPR26GPR31GPR34GPR35GPR37GPR39
GPR50GPR63GRP65GPR68GPR75GPR84GPR87
GPR88GPR132GPR149GPR161GPR183LGR4LGR5
LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2

In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

Receptors

Click here for help

GPR3 C Show summary » More detailed page go icon to follow link

GPR4 C Show summary » More detailed page go icon to follow link

GPR42 C Show summary » More detailed page go icon to follow link

GPR6 C Show summary » More detailed page go icon to follow link

GPR12 C Show summary » More detailed page go icon to follow link

GPR15 C Show summary » More detailed page go icon to follow link

GPR17 C Show summary » More detailed page go icon to follow link

GPR19 C Show summary » More detailed page go icon to follow link

GPR20 C Show summary » More detailed page go icon to follow link

GPR21 C Show summary » More detailed page go icon to follow link

GPR22 C Show summary » More detailed page go icon to follow link

GPR25 C Show summary » More detailed page go icon to follow link

GPR26 C Show summary » More detailed page go icon to follow link

GPR27 C Show summary » More detailed page go icon to follow link

GPR31 C Show summary » More detailed page go icon to follow link

GPR32 C Show summary » More detailed page go icon to follow link

GPR33 C Show summary » More detailed page go icon to follow link

GPR34 C Show summary » More detailed page go icon to follow link

GPR35 C Show summary » More detailed page go icon to follow link

GPR37 C Show summary » More detailed page go icon to follow link

GPR37L1 C Show summary » More detailed page go icon to follow link

GPR39 C Show summary » More detailed page go icon to follow link

GPR45 C Show summary » More detailed page go icon to follow link

GPR50 C Show summary » More detailed page go icon to follow link

GPR52 C Show summary » More detailed page go icon to follow link

GPR61 C Show summary » More detailed page go icon to follow link

GPR62 C Show summary » More detailed page go icon to follow link

GPR63 C Show summary » More detailed page go icon to follow link

GPR65 C Show summary » More detailed page go icon to follow link

GPR68 C Show summary » More detailed page go icon to follow link

GPR75 C Show summary » More detailed page go icon to follow link

GPR78 C Show summary » More detailed page go icon to follow link

GPR79 C Show summary » More detailed page go icon to follow link

GPR82 C Show summary » More detailed page go icon to follow link

GPR83 C Show summary » More detailed page go icon to follow link

GPR84 C Show summary » More detailed page go icon to follow link

GPR85 C Show summary » More detailed page go icon to follow link

GPR87 C Show summary » More detailed page go icon to follow link

GPR88 C Show summary » More detailed page go icon to follow link

GPR101 C Show summary » More detailed page go icon to follow link

GPR132 C Show summary » More detailed page go icon to follow link

GPR135 C Show summary » More detailed page go icon to follow link

GPR139 C Show summary » More detailed page go icon to follow link

GPR141 C Show summary » More detailed page go icon to follow link

GPR142 C Show summary » More detailed page go icon to follow link

GPR146 C Show summary » More detailed page go icon to follow link

GPR148 C Show summary » More detailed page go icon to follow link

GPR149 C Show summary » More detailed page go icon to follow link

GPR150 C Show summary » More detailed page go icon to follow link

GPR151 C Show summary » More detailed page go icon to follow link

GPR152 C Show summary » More detailed page go icon to follow link

GPR153 C Show summary » More detailed page go icon to follow link

GPR160 C Show summary » More detailed page go icon to follow link

GPR161 C Show summary » More detailed page go icon to follow link

GPR162 C Show summary » More detailed page go icon to follow link

GPR171 C Show summary » More detailed page go icon to follow link

GPR173 C Show summary » More detailed page go icon to follow link

GPR174 C Show summary » More detailed page go icon to follow link

GPR176 C Show summary » More detailed page go icon to follow link

GPR182 C Show summary » More detailed page go icon to follow link

GPR183 C Show summary » More detailed page go icon to follow link

LGR4 C Show summary » More detailed page go icon to follow link

LGR5 C Show summary » More detailed page go icon to follow link

LGR6 C Show summary » More detailed page go icon to follow link

MAS1 C Show summary » More detailed page go icon to follow link

MAS1L C Show summary » More detailed page go icon to follow link

MRGPRD C Show summary » More detailed page go icon to follow link

MRGPRE C Show summary » More detailed page go icon to follow link

MRGPRF C Show summary » More detailed page go icon to follow link

MRGPRG C Show summary » More detailed page go icon to follow link

MRGPRX1 C Show summary » More detailed page go icon to follow link

MRGPRX2 C Show summary » More detailed page go icon to follow link

MRGPRX3 C Show summary » More detailed page go icon to follow link

MRGPRX4 C Show summary » More detailed page go icon to follow link

P2RY8 C Show summary » More detailed page go icon to follow link

P2RY10 C Show summary » More detailed page go icon to follow link

TAAR2 C Show summary » More detailed page go icon to follow link

TAAR3 C Show summary » More detailed page go icon to follow link

TAAR4P C Show summary » More detailed page go icon to follow link

TAAR5 C Show summary » More detailed page go icon to follow link

TAAR6 C Show summary » More detailed page go icon to follow link

TAAR8 C Show summary » More detailed page go icon to follow link

TAAR9 C Show summary » More detailed page go icon to follow link

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.