Abbreviated name: S1P
Compound class:
Metabolite
Comment: Sphingosine 1-phosphate (S1P) is a zwitterionic lyso-phospholipid product of the sphingosine biosynthetic pathway. It is a result of the phosphorylation of sphingosine by two well characterised kinases, SPHK1 and SPHK2 (sphingosine kinase 1 and 2). SPHK1 is predominately extracellular and SPHK1 intracellular. Sphingosine itself is produced by the N-deacylation of ceramide by the enzyme ceramidase.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Metabolite |
IUPAC Name |
[(2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate |
Database Links | |
Specialist databases | |
GPCRdb Ligand | sphingosine 1-phosphate |
Other databases | |
BindingDB Ligand | 50158348 |
CAS Registry No. | 26993-30-6 (source: Scifinder) |
ChEBI | CHEBI:37550 |
ChEMBL Ligand | CHEMBL225155 |
GtoPdb PubChem SID | 135651563 |
LIPID MAPS | LMSP01050001 |
PubChem CID | 5283560 |
RCSB PDB Ligand | S1P |
Search Google for chemical match using the InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
Search Google for chemicals with the same backbone | DUYSYHSSBDVJSM |
UniChem Compound Search for chemical match using the InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
Wikipedia | Sphingosine-1-phosphate |
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Sphingosine-1-phosphate (links to external site)
Cat. No. 1370 |