Synonyms: DT-2216
Compound class:
Synthetic organic
Comment: DT2216 is a clinical stage PROTAC type protein degarder. It targets the BCL-XL protein (an anti-apoptotic protein that is overexpressed by some cancers) for degradation via the Von Hippel-Lindau (VHL) E3 ligase, and was developed for potential antitumour activity [2,4]. In vivo (in mice), The target protein binding moiety is based on the BCL-XL protein antagonist navitoclax (ABT-263) [2]. Since VHL is poorly expressed in platelets, DT2216 is significantly less toxic to platelets than parental navitoclax.
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Classification | |
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms |
DT-2216 |
Database Links | |
GtoPdb PubChem SID | 458923757 |
PubChem CID | 139331475 |
Search Google for chemical match using the InChIKey | PXVFFBGSTYQHRO-REQIQPEASA-N |
Search Google for chemicals with the same backbone | PXVFFBGSTYQHRO |
UniChem Compound Search for chemical match using the InChIKey | PXVFFBGSTYQHRO-REQIQPEASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PXVFFBGSTYQHRO-REQIQPEASA-N |