Synonyms: OLT-1177 | OLT1177
Compound class:
Synthetic organic
Comment: Dapansutrile (OLT1177) acts as a NLRP3 inflammasome inhibitor. It is a clinical candidate that is being developed by Olatec Therapeutics. Inhibition of the NLRP3 inflammasome reduces maturation of the pro-inflammatory, disease-associated cytokines IL-1β and IL-18 [3]. Immunoprecipitation and FRET analysis indicates that OLT1177 inhibits inflammasome oligomerization by blocking NLRP3-ASC, and NLRP3-caspase-1 interaction, but may also directly target NLRP3 (as assessed by inhibition of recombinant NLRP3 ATPase activity by dapansutrile) [3].
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
3-methylsulfonylpropanenitrile |
International Nonproprietary Names ![]() |
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INN number | INN |
10228 | dapansutrile |
Synonyms ![]() |
OLT-1177 | OLT1177 |
Database Links ![]() |
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CAS Registry No. | 54863-37-5 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL3989943 |
GtoPdb PubChem SID | 375973244 |
PubChem CID | 12714644 |
Search Google for chemical match using the InChIKey | LQFRYKBDZNPJSW-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | LQFRYKBDZNPJSW |
Search PubMed clinical trials | dapansutrile |
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Search PubMed titles/abstracts | dapansutrile |
UniChem Compound Search for chemical match using the InChIKey | LQFRYKBDZNPJSW-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | LQFRYKBDZNPJSW-UHFFFAOYSA-N |