HsTX1[R14A]   Click here for help

GtoPdb Ligand ID: 9582

Synonyms: KTx 6.3
Immunopharmacology Ligand
Comment: HsTX1[R14A] is a modified version of the scorpion toxin HsTX1 (also known as α-KTx 6.3; wild type peptide sequence ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC). HsTX1 and this modified version are potent blockers of the Kv1.3 potassium channel. The R14A modification confers selectivity for Kv1.3 [1].
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Peptide Sequence Click here for help
Chemical Modification
C-terminally amidated peptide, cross-linked by four disulfide bridges.