HsTX1[R14A]   Click here for help

GtoPdb Ligand ID: 9582

Synonyms: KTx 6.3
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: HsTX1[R14A] is a modified version of the scorpion toxin HsTX1 (also known as α-KTx 6.3; wild type peptide sequence ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC). HsTX1 and this modified version are potent blockers of the Kv1.3 potassium channel. The R14A modification confers selectivity for Kv1.3 [1].
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
References
1. Rashid MH, Huq R, Tanner MR, Chhabra S, Khoo KK, Estrada R, Dhawan V, Chauhan S, Pennington MW, Beeton C et al.. (2014)
A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases.
Sci Rep, 4: 4509. [PMID:24676092]
2. Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C. (2017)
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
Clin Immunol, 180: 45-57. [PMID:28389388]