- Guide to PHARMACOLOGY
Synonyms: Example 1-14 [ WO2014063054]
Compound class: Synthetic organic
Comment: BMX-IN-1 is a selective and irreversible inhibitor (8nM IC50) which covalently modifies Cys496 in the BMX kinase and exhibits antiproliferation efficacy against prostate cancer cells . This compound has a Probe Portal entry SGC BMX-IN-1. A series of analogues of this structure with activity data are disclosed in a 2014 patent 
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Grey N et al.. (2014)
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof.
Patent number: WO2014063054. Assignee: Dana-Farber Institute. Priority date: 19/10/2012. Publication date: 19/07/2014.
2. Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C et al.. (2013)
Discovery of a selective irreversible BMX inhibitor for prostate cancer.
ACS Chem Biol, 8 (7): 1423-8. [PMID:23594111]