- Guide to PHARMACOLOGY
Synonyms: AZ 10606120 | AZ-10606120 | compound 43 [PMID: 19191585] | compound-17 [PMID: 18071294] 
Compound class: Synthetic organic
Comment: AZ10606120 is a negative allosteric modulator of the human P2X7 receptor [3-4]. As a research compound AZ10606120 is being studied for its potential antineoplastic activity .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F. (2012)
Expression of P2X7 receptor increases in vivo tumor growth.
Cancer Res, 72 (12): 2957-69. [PMID:22505653]
2. Guile SD, Alcaraz L, Birkinshaw TN, Bowers KC, Ebden MR, Furber M, Stocks MJ. (2009)
Antagonists of the P2X(7) receptor. From lead identification to drug development.
J Med Chem, 52 (10): 3123-41. [PMID:19191585]
3. Michel AD, Chambers LJ, Walter DS. (2008)
Negative and positive allosteric modulators of the P2X(7) receptor.
Br J Pharmacol, 153 (4): 737-50. [PMID:18071294]
4. Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook J, Livermore D, Senger S. (2008)
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
Br J Pharmacol, 155 (5): 738-51. [PMID:18660826]