Ligand id: 891

Name: lorglumide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 16
Topological polar surface area 86.71
Molecular weight 458.17
XLogP 5.82
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Dunlop J, Brammer N, Ennis C. (1996)
Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene.
Neuropeptides, 30 (4): 359-63. [PMID:8914862]
2. Hughes J, Boden P, Costall B, Domeney A, Kelly E, Horwell DC, Hunter JC, Pinnock RD, Woodruff GN. (1990)
Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
Proc. Natl. Acad. Sci. U.S.A., 87 (17): 6728-32. [PMID:1975695]
3. Iwamoto Y, Yamamoto R, Kuzuya T. (1987)
CR-1409: a potent inhibitor of cholecystokinin-stimulated amylase release and cholecystokinin binding in rat pancreatic acini.
Pancreas, 2 (1): 85-90. [PMID:2437574]