YF-476

Ligand id: 887

Name: YF-476

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 115.79
Molecular weight 498.24
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Boyce M, David O, Darwin K, Mitchell T, Johnston A, Warrington S. (2012)
Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects.
Aliment. Pharmacol. Ther., 36 (2): 181-9. [PMID:22607579]
2. Nilsson I, Monstein HJ, Lindström E, HÃ¥kanson R, Svensson S. (2002)
Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.
Regul. Pept., 103 (1): 29-37. [PMID:11738246]
3. Semple G, Ryder H, Rooker DP, Batt AR, Kendrick DA, Szelke M, Ohta M, Satoh M, Nishida A, Akuzawa S et al.. (1997)
(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.
J. Med. Chem., 40 (3): 331-41. [PMID:9022799]
4. Takinami Y, Yuki H, Nishida A, Akuzawa S, Uchida A, Takemoto Y, Ohta M, Satoh M, Semple G, Miyata K. (1997)
YF476 is a new potent and selective gastrin/cholecystokinin-B receptor antagonist in vitro and in vivo.
Aliment. Pharmacol. Ther., 11 (1): 113-20. [PMID:9042983]