angiopoietin-like 3

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Ligands
angiopoietin-like 3 (Human)

GtoPdb Ligand ID: 8716

Abbreviated name: ANGPTL3

Compound class: Endogenous peptide in human, mouse or rat

Comment: ANGPTL3 is prodominantly secreted in the liver, and has a pro-angiogenic function. The mature peptide is 444 amino acids long, and can be cleaved to form two functionally different sub-peptides: an N-terminal coiled-coil domain-containing chain (involved in lipid metabolism) and a C-terminal fibrinogen chain (angiogenic function).

Species: Human

Summary
Biological activity
References
Structure

References
1. Sleeman MW, Guasrova V, Murphy AJ. (2015) Anti-ANGPTL3 antibodies and uses thereof. Patent number: US9018356 B2. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 17/06/2011. Publication date: 28/04/2015.

References

1. Sleeman MW, Guasrova V, Murphy AJ. (2015)
Anti-ANGPTL3 antibodies and uses thereof.
Patent number: US9018356 B2. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 17/06/2011. Publication date: 28/04/2015.