- Guide to PHARMACOLOGY
Synonyms: SDF-1β | stromal cell-derived factor-1 (SDF-1) | stromal cell-derived factor-1β
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that medaites their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Hesselgesser J, Liang M, Hoxie J, Greenberg M, Brass LF, Orsini MJ, Taub D, Horuk R. (1998)
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.
J. Immunol., 160 (2): 877-83. [PMID:9551924]
2. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T. (1996)
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
Nature, 382 (6592): 635-8. [PMID:8757135]
3. Sierro F, Biben C, Martínez-Muñoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martínez-A C, Mackay CR, Mackay F. (2007)
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
Proc. Natl. Acad. Sci. U.S.A., 104 (37): 14759-64. [PMID:17804806]
4. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S et al.. (1998)
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Nature, 393 (6685): 591-4. [PMID:9634237]
5. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. (1998)
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.
Nature, 393 (6685): 595-9. [PMID:9634238]