- Guide to PHARMACOLOGY
Synonyms: NMS P937 | NMS-1286937 | NMS-P937 | NMS1286937
Compound class: Synthetic organic
Comment: Onvansertib (NMS-P937) is an orally available, selective polo-like kinase 1 (PLK1) inhibitor. Its discovery is described in , where it is compound 7g.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Beria I, Bossi RT, Brasca MG, Caruso M, Ceccarelli W, Fachin G, Fasolini M, Forte B, Fiorentini F, Pesenti E et al.. (2011)
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.
Bioorg Med Chem Lett, 21 (10): 2969-74. [PMID:21470862]