- Guide to PHARMACOLOGY
Synonyms: GNF-Pf-2024 | scriptide
Compound class: Synthetic organic
Comment: Scriptaid is a potent inhibitor of HDACs 1, 2, 3 and 6 , with lower potencies for other Class I and II HDACs .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. (2010)
Chemical phylogenetics of histone deacetylases.
Nat Chem Biol, 6 (3): 238-243. [PMID:20139990]
2. Su GH, Sohn TA, Ryu B, Kern SE. (2000)
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.
Cancer Res, 60 (12): 3137-42. [PMID:10866300]
3. Takai N, Ueda T, Nishida M, Nasu K, Narahara H. (2006)
A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells.
Int J Mol Med, 17 (2): 323-9. [PMID:16391833]