- Guide to PHARMACOLOGY
Synonyms: Aloxi® | aurothioglucose | RS-25259-197
palonosetron is an approved drug (FDA (2003), EMA (2009))
Compound class: Synthetic organic
Comment: Palonosetron is a 'serton' family drug, that is a serotonin 5-HT3 antagonist. Most setrons are antiemetics, apart from alosetron and cilansetron, which are irritable bowel syndrome therapeutics. Setrons are the most widely prescribed antiemetic drugs used in the management of chemotherapy-induced nausea and vomiting (CINV).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: palonosetron
1. De Leon A. (2006)
Palonosetron (Aloxi): a second-generation 5-HT₃ receptor antagonist for chemotherapy-induced nausea and vomiting.
Proc (Bayl Univ Med Cent), 19 (4): 413-6. [PMID:17106506]
2. Moura Barbosa AJ, De Rienzo F, Ramos MJ, Menziani MC. (2010)
Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors.
Eur J Med Chem, 45 (11): 4746-60. [PMID:20724042]