droxidopa   Click here for help

GtoPdb Ligand ID: 7391

Synonyms: L-DOPS | Northera® | SM-5688
Approved drug
droxidopa is an approved drug (FDA (2014))
Compound class: Synthetic organic
Comment: As droxidopa is a prodrug for noradrenaline, its effects will be through noradrenaline activation of adrenoceptors. The cellular effect is dependent upon adrenoceptor subtype expression on target cells.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 124.01
Molecular weight 213.06
XLogP -2.79
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)C(C(c1ccc(c(c1)O)O)O)N
Isomeric SMILES OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N
InChI InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
1. Croy CH, Chan WY, Castetter AM, Watt ML, Quets AT, Felder CC. (2016)
Characterization of PCS1055, a novel muscarinic M4 receptor antagonist.
Eur J Pharmacol, 782: 70-6. [PMID:27085897]
2. Goldstein DS. (2006)
L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug.
Cardiovasc Drug Rev, 24 (3-4): 189-203. [PMID:17214596]