Synonyms: BL-191 | Trental®
pentoxifylline is an approved drug (FDA (1984))
Compound class:
Synthetic organic
Comment: Pentoxifylline is a methylated xanthine derivative drug which acts as a competitive non-selective phosphodiesterase (PDE) inhibitor [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: pentoxifylline |
|
References |
1. Essayan DM. (2001)
Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol, 108 (5): 671-80. [PMID:11692087] |
2. Kim SA, Marshall MA, Melman N, Kim HS, Müller CE, Linden J, Jacobson KA. (2002)
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem, 45 (11): 2131-8. [PMID:12014951] |
3. Konrad FM, Neudeck G, Vollmer I, Ngamsri KC, Thiel M, Reutershan J. (2013)
Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent. FASEB J, 27 (9): 3524-35. [PMID:23699177] |
4. Trevethick MA, Mantell SJ, Stuart EF, Barnard A, Wright KN, Yeadon M. (2008)
Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions. Br J Pharmacol, 155 (4): 463-74. [PMID:18846036] |
5. Ward A, Clissold SP. (1987)
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs, 34 (1): 50-97. [PMID:3308412] |