- Guide to PHARMACOLOGY
Synonyms: Arcalyst® | IL-1 Trap | interleukin-1 Trap
rilonacept is an approved drug (FDA (2008), EMA (2009))
Compound class: Antibody
Comment: Rilonacept is a fusion protein consisting of the binding domains of the IL-1 receptor (IL-1R) and the IL-1 receptor accessory protein (IL-1RAcP) linked to the Fc portion of human IgG1.
1. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N et al.. (2008)
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Arthritis Rheum., 58 (8): 2443-52. [PMID:18668535]
2. McDermott MF. (2009)
Rilonacept in the treatment of chronic inflammatory disorders.
Drugs Today, 45 (6): 423-30. [PMID:19649332]