GtoPdb Ligand ID: 6790

Synonyms: Arcalyst® | IL-1 Trap | interleukin-1 Trap
rilonacept is an approved drug (FDA (2008), EMA (2009))
Compound class: Antibody
Comment: Rilonacept is a fusion protein consisting of the binding domains of the IL-1 receptor (IL-1R) and the IL-1 receptor accessory protein (IL-1RAcP) linked to the Fc portion of human IgG1.
Immunopharmacology Disease
Disease X-Refs Comment References
Muckle-Wells syndrome OMIM: 191900
Orphanet: ORPHA575
Approved drug for Muckle-Wells syndrome.
Familial cold autoinflammatory syndrome 1; FCAS1 OMIM: 120100
Orphanet: ORPHA47045
Approved drug for FCAS1.
CINCA syndrome OMIM: 607115
Orphanet: ORPHA1451
Approved drug for CINCA syndrome.