- Guide to PHARMACOLOGY
Synonyms: IL-17E | interleukin-17E | interleukin-25
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-25 shares sequence similarity with IL-17 family proteins, and shares the IL17RB cytokine receptor with IL-17B.
1. Benatar T, Cao MY, Lee Y, Lightfoot J, Feng N, Gu X, Lee V, Jin H, Wang M, Wright JA et al.. (2010)
IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo.
Cancer Immunol Immunother, 59 (6): 805-17. [PMID:20012860]
2. Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA et al.. (2006)
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
J Exp Med, 203 (4): 843-9. [PMID:16606667]