- Guide to PHARMACOLOGY
Synonyms: benzyl quinolone carboxylic acid
Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M. (2014)
Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
J Biol Chem, 289 (48): 33701-11. [PMID:25326383]
2. Abdul-Ridha A, López L, Keov P, Thal DM, Mistry SN, Sexton PM, Lane JR, Canals M, Christopoulos A. (2014)
Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
J Biol Chem, 289 (9): 6067-79. [PMID:24443568]
3. Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. (2012)
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.
J Biol Chem, 287 (1): 650-9. [PMID:22086918]
4. Ma L, Seager MA, Seager M, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G et al.. (2009)
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Proc Natl Acad Sci USA, 106 (37): 15950-5. [PMID:19717450]