SU11274   Click here for help

GtoPdb Ligand ID: 5057

Synonyms: Met kinase Inhibitor | SU-11274
PDB Ligand
Compound class: Synthetic organic
Comment: SU11274 is a selective Met inhibitor [6].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 114.2
Molecular weight 567.17
XLogP 3.74
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCN(CC1)C(=O)c1c(C)[nH]c(c1C)C=C1C(=O)Nc2c1cc(cc2)S(=O)(=O)N(c1cccc(c1)Cl)C
Isomeric SMILES CN1CCN(CC1)C(=O)c1c(C)[nH]c(c1C)/C=C/1\C(=O)Nc2c1cc(cc2)S(=O)(=O)N(c1cccc(c1)Cl)C
InChI InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Haddad R, Lipson KE, Webb CP. (2001)
Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.
Anticancer Res, 21 (6B): 4243-52. [PMID:11908677]
4. Longati P, Comoglio PM, Bardelli A. (2001)
Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.
Curr Drug Targets, 2 (1): 41-55. [PMID:11465538]
5. Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R. (2002)
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.
Cytokine Growth Factor Rev, 13 (1): 41-59. [PMID:11750879]
6. Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S et al.. (2003)
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Mol Cancer Ther, 2 (11): 1085-92. [PMID:14617781]