aciclovir   Click here for help

GtoPdb Ligand ID: 4829

Synonyms: acyclovir | Zovirax®
Approved drug PDB Ligand
aciclovir is an approved drug (FDA (1982, prior history not available))
Compound class: Synthetic organic
Comment: Aciclovir is a nucleoside analogue antiviral drug.
Aciclovir is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

aciclovir is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 119.05
Molecular weight 225.09
XLogP -0.75
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCCOCn1cnc2c1nc(N)[nH]c2=O
Isomeric SMILES OCCOCn1cnc2c1nc(N)[nH]c2=O
InChI InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChI Key MKUXAQIIEYXACX-UHFFFAOYSA-N
References
1. Allaudeen HS, Descamps J, Sehgal RK. (1982)
Mode of action of acyclovir triphosphate on herpesviral and cellular DNA polymerases.
Antiviral Res, 2 (3): 123-33. [PMID:6291456]
2. Datta AK, Colby BM, Shaw JE, Pagano JS. (1980)
Acyclovir inhibition of Epstein-Barr virus replication.
Proc Natl Acad Sci USA, 77 (9): 5163-6. [PMID:6254061]
3. Gnann Jr JW, Barton NH, Whitley RJ. (1983)
Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications.
Pharmacotherapy, 3 (5): 275-83. [PMID:6359082]
4. Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K. (2007)
Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Biochem Pharmacol, 74 (2): 359-71. [PMID:17509534]