flunitrazepam   Click here for help

GtoPdb Ligand ID: 4193

Synonyms: Narcozep® | Rohypnol®
Approved drug
flunitrazepam is an approved drug
Compound class: Synthetic organic
Comment: A benzodiazepine with pharmacologic actions similar to those of diazepam. Due to illicit use of this drug importation has been banned by the US, but medicinal use is approved in other countries.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 75.81
Molecular weight 313.09
XLogP 2.35
No. Lipinski's rules broken 0
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Canonical SMILES CN1C(=O)CN=C(c2c1ccc(c2)[N+](=O)[O-])c1ccccc1F
Isomeric SMILES CN1C(=O)CN=C(c2c1ccc(c2)[N+](=O)[O-])c1ccccc1F
InChI InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
1. Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ. (1996)
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
Mol Pharmacol, 49 (2): 253-9. [PMID:8632757]
2. Krishek BJ, Moss SJ, Smart TG. (1998)
Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors.
J Physiol (Lond.), 507 ( Pt 3): 639-52. [PMID:9508826]