Synonyms: SB-290157
Compound class:
Synthetic organic
Comment: SB290157 is an antagonist of the human Complement C3a receptor (C3aR).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD et al.. (2001)
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J Immunol, 166 (10): 6341-8. [PMID:11342658] |
2. Li XX, Kumar V, Clark RJ, Lee JD, Woodruff TM. (2020)
The "C3aR Antagonist" SB290157 is a Partial C5aR2 Agonist. Front Pharmacol, 11: 591398. [PMID:33551801] |