[3H]pirenzepine   Click here for help

GtoPdb Ligand ID: 3272

Synonyms: [3H]PZ
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 74.23
Molecular weight 351.17
XLogP 1.32
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2
Isomeric SMILES O=C(n1c2ccccc2c(=O)[nH]c2c1nccc2)CN1CCN(CC1)C([3H])([3H])[3H]
InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/i1T3
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The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding.
Brain Sci, 10 (2). [PMID:32079174]
2. Eveleigh P, Hulme EC, Schudt C, Birdsall NJ. (1989)
The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes.
Mol Pharmacol, 35 (4): 477-83. [PMID:2704371]
3. Hammer R, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. (1980)
Pirenzepine distinguishes between different subclasses of muscarinic receptors.
Nature, 283 (5742): 90-2. [PMID:7350532]
4. Scarr E, Dean B. (2008)
Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?.
J Neurochem, 107 (5): 1188-95. [PMID:18957051]
5. Valuskova P, Farar V, Forczek S, Krizova I, Myslivecek J. (2018)
Autoradiography of 3H-pirenzepine and 3H-AFDX-384 in Mouse Brain Regions: Possible Insights into M1, M2, and M4 Muscarinic Receptors Distribution.
Front Pharmacol, 9: 124. [PMID:29515448]
6. Watson M, Roeske WR, Johnson PC, Yamamura HI. (1984)
[3H]Pirenzepine identifies putative M1 muscarinic receptors in human stellate ganglia.
Brain Res, 290 (1): 179-82. [PMID:6546354]