- Guide to PHARMACOLOGY
nisoldipine is an approved drug (FDA (1995))
Compound class: Synthetic organic
Comment: Nisoldipine is a dihydropyridine calcium channel blocker.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: nisoldipine
1. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kühbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. (2000)
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
J Biol Chem, 275 (50): 39193-9. [PMID:10973973]
2. Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K et al.. (2004)
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Cell, 119 (1): 19-31. [PMID:15454078]
3. Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N. (2003)
Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.
J Biol Chem, 278 (42): 40837-41. [PMID:12900400]