PACAP-38   Click here for help

GtoPdb Ligand ID: 2258

Synonyms: pituitary adenylate cyclase activating polypeptide-38
Comment: Sequences of human, mouse, rat and sheep PACAP-38 are identical.

PACAP-38 has been proposed as a novel target for the teament of migraine [6]. In response, Alder BioPharmaceuticals have developed an anti-PACAP-38 monoclonal antibody (ALD1910) that has progressed to clinical evaluation (NCT04197349).
Species: Human, Mouse, Rat
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1. Ciccarelli E, Svoboda M, De Neef P, Di Paolo E, Bollen A, Dubeaux C, Vilardaga JP, Waelbroeck M, Robberecht P. (1995)
Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells.
Eur J Pharmacol, 288 (3): 259-67. [PMID:7774670]
2. Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL. (1999)
N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.
J Neuroendocrinol, 11 (12): 941-9. [PMID:10583729]
3. Dickson L, Aramori I, McCulloch J, Sharkey J, Finlayson K. (2006)
A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology.
Neuropharmacology, 51 (6): 1086-98. [PMID:16930633]
4. Gaudin P, Couvineau A, Maoret JJ, Rouyer-Fessard C, Laburthe M. (1996)
Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.
Eur J Pharmacol, 302 (1-3): 207-14. [PMID:8791009]
5. Moro O, Lerner EA. (1997)
Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist.
J Biol Chem, 272 (2): 966-70. [PMID:8995389]
6. Rubio-Beltrán E, Correnti E, Deen M, Kamm K, Kelderman T, Papetti L, Vigneri S, MaassenVanDenBrink A, Edvinsson L, European Headache Federation School of Advanced Studies (EHF-SAS). (2018)
PACAP38 and PAC1 receptor blockade: a new target for headache?.
J Headache Pain, 19 (1): 64. [PMID:30088106]