- Guide to PHARMACOLOGY
Synonyms: pituitary adenylate cyclase activating polypeptide-38
Compound class: Endogenous peptide in human, mouse or rat
Comment: Sequences of human, mouse, rat and sheep PACAP-38 are identical.
PACAP-38 has been proposed as a novel target for the teament of migraine . In response, Alder BioPharmaceuticals have developed an anti-PACAP-38 monoclonal antibody (ALD1910) that has progressed to clinical evaluation (NCT04197349).
Species: Human, Mouse, Rat
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Ciccarelli E, Svoboda M, De Neef P, Di Paolo E, Bollen A, Dubeaux C, Vilardaga JP, Waelbroeck M, Robberecht P. (1995)
Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells.
Eur J Pharmacol, 288 (3): 259-67. [PMID:7774670]
2. Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL. (1999)
N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.
J Neuroendocrinol, 11 (12): 941-9. [PMID:10583729]
3. Dickson L, Aramori I, McCulloch J, Sharkey J, Finlayson K. (2006)
A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology.
Neuropharmacology, 51 (6): 1086-98. [PMID:16930633]
4. Gaudin P, Couvineau A, Maoret JJ, Rouyer-Fessard C, Laburthe M. (1996)
Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.
Eur J Pharmacol, 302 (1-3): 207-14. [PMID:8791009]
5. Moro O, Lerner EA. (1997)
Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist.
J Biol Chem, 272 (2): 966-70. [PMID:8995389]
6. Rubio-Beltrán E, Correnti E, Deen M, Kamm K, Kelderman T, Papetti L, Vigneri S, MaassenVanDenBrink A, Edvinsson L, European Headache Federation School of Advanced Studies (EHF-SAS). (2018)
PACAP38 and PAC1 receptor blockade: a new target for headache?.
J Headache Pain, 19 (1): 64. [PMID:30088106]