- Guide to PHARMACOLOGY
Synonyms: SB 207256 | SB 207266 | SB 207266-A | SB207256
Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N et al.. (2004)
The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.
Br J Pharmacol, 143 (5): 549-60. [PMID:15466450]
2. Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A. (1997)
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.
Neuroreport, 8 (15): 3189-96. [PMID:9351641]
3. Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G. (2001)
Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
Bioorg Med Chem, 9 (8): 2119-28. [PMID:11504648]