piboserod   Click here for help

GtoPdb Ligand ID: 225

Synonyms: SB 207256 | SB 207266 | SB 207266-A | SB207256
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 46.5
Molecular weight 369.24
XLogP 5.48
No. Lipinski's rules broken 1
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Canonical SMILES CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2
Isomeric SMILES CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2
InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
1. Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N et al.. (2004)
The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.
Br J Pharmacol, 143 (5): 549-60. [PMID:15466450]
2. Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A. (1997)
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.
Neuroreport, 8 (15): 3189-96. [PMID:9351641]
3. Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G. (2001)
Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
Bioorg Med Chem, 9 (8): 2119-28. [PMID:11504648]