peptide YY   Click here for help

GtoPdb Ligand ID: 1515

Abbreviated name: PYY
Synonyms: peptide tyrosine tyrosine
Compound class: Endogenous peptide in human, mouse or rat
Comment: The mouse, rat and pig sequences are identical. See the post-translational modifications for possible species-differences
Species: Mouse, Rat, Pig
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chen Z, Eriste E, Jonsson AP, Norberg A, Nepomuceno D, Lovenberg TW, Bergman T, Efendic S, Jörnvall H, Sillard R. (2001)
Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity.
FEBS Lett, 492 (1-2): 119-22. [PMID:11248248]
2. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997)
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Peptides, 18 (3): 397-401. [PMID:9145427]
3. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL. (1995)
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.
J Biol Chem, 270 (45): 26758-61. [PMID:7592910]
4. Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M. (2001)
The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.
Mol Pharmacol, 60 (1): 124-34. [PMID:11408607]
5. Gregor P, Millham ML, Feng Y, DeCarr LB, McCaleb ML, Cornfield LJ. (1996)
Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
FEBS Lett, 381: 58-62. [PMID:8641440]
6. Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J et al.. (1996)
Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
J Biol Chem, 271 (42): 26315-9. [PMID:8824284]
7. Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA. (1997)
A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Peptides, 18 (4): 609-12. [PMID:9210181]