Compound class:
Synthetic organic
Comment: Representations of the stereochemistry of CPCCOEt in the literature vary, with the majority of sources specifying a 'flat' structure (as our listed references do), while a few detail (-)CPCCOEt.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ. (2018)
"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands. Mol Pharmacol, 93 (5): 504-514. [PMID:29514854] |
2. Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. (2003)
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol, 63 (5): 1082-93. [PMID:12695537] |
3. Lavreysen H, Le Poul E, Van Gompel P, Dillen L, Leysen JE, Lesage AS. (2002)
Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells. Mol Pharmacol, 61 (5): 1244-54. [PMID:11961143] |
4. Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R. (1999)
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol Pharmacol, 55 (3): 453-61. [PMID:10051528] |