KS0365   Click here for help

GtoPdb Ligand ID: 12552

Compound class: Synthetic organic
Comment: KS0365 is an activator of the transient receptor potential vanilloid 3 (TRPV3) channel [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 250.76
XLogP 3.1
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(C)C1=C(C(CC1)C2=CC(=CC=C2O)C)Cl
Isomeric SMILES ClC=1C(CCC1C(C)C)C2=C(C=CC(=C2)C)O
InChI InChI=1S/C15H19ClO/c1-9(2)11-5-6-12(15(11)16)13-8-10(3)4-7-14(13)17/h4,7-9,12,17H,5-6H2,1-3H3
InChI Key OSGBHOYVDQQKET-UHFFFAOYSA-N
References
1. Maier M, Olthoff S, Hill K, Zosel C, Magauer T, Wein LA, Schaefer M. (2022)
KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration.
Br J Pharmacol, 179 (24): 5290-5304. [PMID:35916168]