Compound class:
Synthetic organic
Comment: TAK-071 is a muscarinic M1 receptor positive allosteric modulator [1-2]. It has been shown to improve cognitive function in in vivo models.
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References |
1. Kurimoto E, Yamada R, Hirakawa T, Kimura H. (2021)
Therapeutic potential of TAK-071, a muscarinic M1 receptor positive allosteric modulator with low cooperativity, for the treatment of cognitive deficits and negative symptoms associated with schizophrenia. Neurosci Lett, 764: 136240. [PMID:34509568] |
2. Sako Y, Kurimoto E, Mandai T, Suzuki A, Tanaka M, Suzuki M, Shimizu Y, Yamada M, Kimura H. (2019)
TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology, 44 (5): 950-960. [PMID:30089885] |
3. Yin W, Mamashli F, Buhl DL, Khudyakov P, Volfson D, Martenyi F, Gevorkyan H, Rosen L, Simen AA. (2022)
Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects. Br J Clin Pharmacol, 88 (2): 600-612. [PMID:34240455] |