Synonyms: Deptran® | P-3693A | Sinequan®
doxepin is an approved drug (FDA (1969))
Compound class:
Synthetic organic
Comment: Doxepin inhibits the sodium-dependent noradrenaline transporter SLC6A2.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Auerbach SS, DrugMatrix® and ToxFX® Coordinator National Toxicology Program.
National Toxicology Program: Dept of Health and Human Services. Accessed on 02/05/2014. Modified on 02/05/2014. DrugMatrix, https://ntp.niehs.nih.gov/drugmatrix/index.html |
2. Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H, Leurs R. (2002)
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. J Pharmacol Exp Ther, 302 (1): 328-36. [PMID:12065734] |
3. Kubo N, Shirakawa O, Kuno T, Tanaka C. (1987)
Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay. Jpn J Pharmacol, 43 (3): 277-82. [PMID:2884340] |
4. Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997)
Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 340 (2-3): 249-58. [PMID:9537821] |