SVEP1

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Ligands
SVEP1 (Human)

GtoPdb Ligand ID: 12044

Synonyms: polydom

Compound class: Endogenous peptide in human, mouse or rat

Comment: SVEP1 is a large secreted extracellular matrix, multi-domain, multi-function protein with roles in normal physiological processes and disease states [1-3,5]. It binds to the integrins α9β1 [6] and α4β1 [4].

Species: Human

References
1. Chen L, Liu D, Yi X, Qi L, Tian X, Sun B, Dong Q, Han Z, Li Q, Song T et al.. (2020) The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway. Cell Death Dis, 11 (5): 320. [PMID:32371982]
2. Jung IH, Elenbaas JS, Alisio A, Santana K, Young EP, Kang CJ, Kachroo P, Lavine KJ, Razani B, Mecham RP et al.. (2021) SVEP1 is a human coronary artery disease locus that promotes atherosclerosis. Sci Transl Med, 13 (586). DOI: 10.1126/scitranslmed.abe0357 [PMID:33762433]
3. Michelini S, Amato B, Ricci M, Serrani R, Veselenyiova D, Kenanoglu S, Kurti D, Dautaj A, Baglivo M, Compagna R et al.. (2021) SVEP1 is important for morphogenesis of lymphatic system: Possible implications in lymphedema. Lymphology, 54 (1): 12-22. [PMID:34506084]
4. Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA et al.. (2022) The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1. Br J Pharmacol, 179 (21): 4958-4973. [PMID:35802072]
5. Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL et al.. (2016) Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med, 374 (12): 1134-44. [PMID:26934567]
6. Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K. (2012) Polydom/SVEP1 is a ligand for integrin α9β1. J Biol Chem, 287 (30): 25615-30. [PMID:22654117]

References

1. Chen L, Liu D, Yi X, Qi L, Tian X, Sun B, Dong Q, Han Z, Li Q, Song T et al.. (2020)
The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway.
Cell Death Dis, 11 (5): 320. [PMID:32371982]

2. Jung IH, Elenbaas JS, Alisio A, Santana K, Young EP, Kang CJ, Kachroo P, Lavine KJ, Razani B, Mecham RP et al.. (2021)
SVEP1 is a human coronary artery disease locus that promotes atherosclerosis.
Sci Transl Med, 13 (586). DOI: 10.1126/scitranslmed.abe0357 [PMID:33762433]

3. Michelini S, Amato B, Ricci M, Serrani R, Veselenyiova D, Kenanoglu S, Kurti D, Dautaj A, Baglivo M, Compagna R et al.. (2021)
SVEP1 is important for morphogenesis of lymphatic system: Possible implications in lymphedema.
Lymphology, 54 (1): 12-22. [PMID:34506084]

4. Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA et al.. (2022)
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.
Br J Pharmacol, 179 (21): 4958-4973. [PMID:35802072]

5. Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL et al.. (2016)
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
N Engl J Med, 374 (12): 1134-44. [PMID:26934567]

6. Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K. (2012)
Polydom/SVEP1 is a ligand for integrin α9β1.
J Biol Chem, 287 (30): 25615-30. [PMID:22654117]