R3/I5- SmBiT   Click here for help

GtoPdb Ligand ID: 11911

 Ligand is labelled
Compound class: Peptide or derivative
Comment: R3/I5-SmBiT is a modified analogue of the RXFP3/4 peptide agonist R3/I5, to which a low-affinity small complementation tag (SmBiT) is ligated to the A-chain N terminus [1]. It is used in a NanoLuc complementation assay (NanoBiT) to monitor receptor-ligand interaction.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Hu MJ, Shao XX, Li HZ, Nie WH, Wang JH, Liu YL, Xu ZG, Guo ZY. (2018)
Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation.
Amino Acids, 50 (8): 1111-1119. [PMID:29770870]