Synonyms: (+)-Tetrandrine | (S,S)-Tetrandrine | D-Tetrandrine | Tetrandrin
tetrandrine is an approved drug (China)
Compound class:
Synthetic organic
Comment: Tetrandrine is a compound that can be extracted from the Stephania tetrandra vine, or synthesised chemically. It has been demonstrated to act as an inhibitor of multiple ion channels, including two-pore channels 1 and 2 (TPC1/2), and L- and T-type calcium channels [2-3]. The TPC calcium channels appear to be important for Ebola virus infection of host cells, and in vitro either ablation of TPC expression or tetrandrine-mediated inhibition of TPC channels reduces Ebola infection (IC50 55 nM) [3].
SARS-CoV-2 infection (COVID-19): Tetrandrine is being studied in clinical trial for potential to treat COVID-19. The biological and pharmacological rationale for this use was reviewed in [1]. |
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References |
1. Heister PM, Poston RN. (2020)
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19. Pharmacol Res Perspect, 8 (5): e00653. [PMID:32930523] |
2. King VF, Garcia ML, Himmel D, Reuben JP, Lam YK, Pan JX, Han GQ, Kaczorowski GJ. (1988)
Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin. J Biol Chem, 263 (5): 2238-44. [PMID:2448307] |
3. Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. (2015)
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science, 347 (6225): 995-8. [PMID:25722412] |
4. Sun J, Song P, Wang Y, Chen Y. (2019)
Clinical efficacy of acetylcysteine combined with tetrandrine tablets in the treatment of silicosis and the effect on serum IL-6 and TNF-α. Exp Ther Med, 18 (5): 3383-3388. [PMID:31602212] |