- Guide to PHARMACOLOGY
Synonyms: hPD-1 mAb 7(1.2)  | INCMGA0012 | MGA012
Compound class: Antibody
Comment: Retifanlimab (MGA012) is a clinical stage humanized IgG4 anti-PD-1 monoclonal antibody. It was developed by MacroGenics for anti-cancer potential. Retifanlimab blocks the interation between PD-1 and its ligands PD-L1/2, and it acts as an immune checkpoint inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Catenacci DV, Rosales M, Chung HC, H Yoon H, Shen L, Moehler M, Kang YK. (2020)
MAHOGANY: margetuximab combination in HER2+ unresectable/metastatic gastric/gastroesophageal junction adenocarcinoma.
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Pd-1-binding molecules and methods use thereof.
Patent number: WO2017019846A1. Assignee: Macrogenics, Inc.. Priority date: 30/07/2015. Publication date: 02/02/2017.