retifanlimab   Click here for help

GtoPdb Ligand ID: 11583

Synonyms: hPD-1 mAb 7(1.2) [3] | INCMGA0012 | MGA012
Compound class: Antibody
Comment: Retifanlimab (MGA012) is a clinical stage humanized IgG4 anti-PD-1 monoclonal antibody. It was developed by MacroGenics for anti-cancer potential. Retifanlimab blocks the interation between PD-1 and its ligands PD-L1/2, and it acts as an immune checkpoint inhibitor.
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 (CD279) Hs Antibody Binding 8.8 pKd - 3
pKd 8.8 (Kd 1.5x10-9 M) [3]
Description: Binding affinity for immobilised PD-1 determinet bt SPR assay
programmed cell death 1 (CD279) Monkey Antibody Binding 8.3 pKd - 3
pKd 8.3 (Kd 4.6x10-9 M) [3]
Description: Binding affinity for immobilised PD-1 determinet bt SPR assay