spexin-1   Click here for help

GtoPdb Ligand ID: 11417

Compound class: Endogenous peptide in human, mouse or rat
Comment: Spexin-1 has been identified as an agonist of galanin receptors GALR2 and GALR3 [1-2]. It is a cleavage product of the 116 amino acid spexin precursor which is cleaved into two chains: spexin-1 and spexin-2 (FISDQSRRKDLSDRPLPE).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, Kim K, Vaudry H, Seong JY. (2014)
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Endocrinology, 155 (5): 1864-73. [PMID:24517231]
2. Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, Birney E, Rosenthal N, Gross C. (2007)
Identification of novel peptide hormones in the human proteome by hidden Markov model screening.
Genome Res, 17 (3): 320-7. [PMID:17284679]