Compound class:
Synthetic organic
Comment: Compound 2 is a representative compound from a novel class of hybrid molecules, combining structural domains from azithromycin and chloroquine. It consists of an azalide scaffold linked to a chloroquinoline aromate and demonstrates improved antimalarial efficacy over the parent compounds [1].
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References |
1. Peric M, Pešić D, Alihodžić S, Fajdetić A, Herreros E, Gamo FJ, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer-Bazaga S, Martínez MS et al.. (2021)
A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides. Br J Pharmacol, 178 (2): 363-377. [PMID:33085774] |