- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: Compound 11c has been identified as a representative analogue for the 2-pyrazolyl quinolone series of antimalarial compounds .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Hong WD, Leung SC, Amporndanai K, Davies J, Priestley RS, Nixon GL, Berry NG, Hasnain SS, Antonyuk S, Ward SA et al.. (2018)
Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties.
ACS Med Chem Lett, 9 (12): 1205-1210. [PMID:30613327]
2. O'Neill P, Biagini G, Ward SA, Berry NG, Nixon G, Amewu RK, Pidathala C, Hong WD, Gibbons P, Leung SC, Pacorel B, Sharma R, Lawrenson AS, Shone AE, Srivastava A, Warman AJ. (2012)
Patent number: WO2012069856A1. Assignee: Liverpool School of Tropical Medicine. Priority date: 26/11/2010. Publication date: 31/05/2012.