- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: S416 is an inhibitor of dihydroorotate dehydrogenase (DHODH) . It has been explored for antiviral activity against RNA viruses, including SARS-CoV-2, based on the rationale that viruses depend on host pyrimidine synthesis to maintain their replication, and that therefore inhibiting a crucial step in this synthetic pathway should limit viral replication. Mechanistically, S416 binds at the putative ubiquinone binding tunnel within the DHODH active site.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X et al.. (2020)
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell, 11 (10): 723-739. [PMID:32754890]