Synonyms: ORM10962
Compound class:
Synthetic organic
Comment: ORM-10962 is a selective inhibitor of the SCL8 (NCX) Na+/Ca2+ exchangers [1]. It blocks both inward and outward NCX currents. ORM-10962 has been used in vivo to demonstrate that NCX blockade may contribute to the prevention of delayed afterdepolarization-based arrhythmogenesis.
|
|
References |
1. Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K et al.. (2016)
The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS ONE, 11 (11): e0166041. [PMID:27832106] |